Does initiation of low-dose aspirin improve pregnancy outcomes in women at high risk for preeclampsia?

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EVIDENCE-BASED ANSWERLow-dose aspirin reduces the risk of preeclampsia and its complications (preterm birth, intrauterine growth restriction, and perinatal death) in high-risk pregnant women (SOR: A, consistent meta-analyses). The exact dose (60 or 100 mg) and the optimum time of initiation are not entirely clear (No SOR, conflicting meta-analyses).

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