In which individuals should aspirin be used for primary prevention of cardiovascular disease?

    loading  Checking for direct PDF access through Ovid



In patients older than 40 years without cardiovascular disease (CVD), aspirin use decreases the risk of nonfatal myocardial infarction (MI) by 22% and allcause mortality by 6%. However, aspirin has no effect on stroke or all-cause mortality and may increase the risk of hemorrhage and other nontrivial bleeding (SOR: B, meta-analysis of heterogeneous RCTs). Low-dose aspirin should be given to adults 50 to 69 years old with a 10% or higher 10-year risk of CVD who are not at increased risk of bleeding and have a life expectancy of at least 10 years. The decision should be individualized for adults 60 to 69 years old (SOR: C, expert opinion).

Related Topics

    loading  Loading Related Articles