Impaired Coronary Microvascular Function and Its Association with Disease Duration and Inflammation in Patients with Psoriasis

    loading  Checking for direct PDF access through Ovid

Abstract

Subjects

Thirty-six patients with psoriasis and 56 healthy volunteers were included in this study.

Methods

Echocardiographic examination included transmitral peak flow velocities of the early phase (E) and late phase (A) of the mitral inflow, left ventricular myocardial velocity measurements, and coronary flow reserve (CFR) measurement.

Results

Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending artery (LAD) was significantly higher in the psoriasis group. However, hyperemic DPFV was slightly lower and CFR (2.19 ± 0.39 vs. 2.60 ± 0.31, P < 0.0001) was significantly lower in the psoriasis group than in the control group. CFR was significantly and inversely correlated with disease duration, Psoriasis Area and Severity Index (PASI) score, and hsCRP.

Conclusion

CFR is decreased in patients with psoriasis, and it correlates to disease duration, PASI score, and inflammation.

Related Topics

    loading  Loading Related Articles