The present study was designed to compare clinically and radiographically between leukocyte-platelet-rich fibrin (L-PRF) and L-PRF mixed with bone graft [platelet-rich fibrin (PRF) block] in ridge splitting technique (RST) with simultaneous implant placement. This study was carried out on 30 patients with partial edentulous narrow anterior maxillary ridge. Patients were divided randomly into three equal groups (group I was treated with RST and simultaneous implant placement into their ridge without any bone graft; group II was treated with RST and simultaneous implant placement into their ridge associated with L-PRF; and group III was treated with RST and simultaneous implant placement into their ridge associated with a PRF block (L-PRF mixed with Easy-Graft Crystal). Amniotic membrane was used in all groups as a cover for distracted area under flaps. Patients were evaluated clinically to assess probing depth and implant stability quotient, and radiographically to assess the alveolar ridge width, marginal bone level, and bone density measurement parameters at 3, 6, 9, and 12 months. The results of the present study showed no significant difference of postpartum depression and implant stability quotient between the groups at the different intervals but there was a superiority of the PRF block group in marginal bone level and bone density, with statistically significant difference, especially at the end of the observation period.