The impact of butorphanol in rat temporomandibular joint inflammation

    loading  Checking for direct PDF access through Ovid

Abstract

Objective

The objective of the present study was to evaluate the anti-inflammatory effect of butorphanol in formalin-induced temporomandibular joint (TMJ) inflammation in rats.

Materials and methods

A total of 30 adult male Wistar rats were randomly divided into three groups of 10 rats each – group 1, the saline control group: rats were subjected to TMJ injection of saline; group 2, the formalin control group: rats were subjected to TMJ injection of formalin and did not receive any treatment; group 3, the butorphanol-treated group: rats received TMJ injection of 0.4 mg/kg butorphanol 30 min after TMJ injection of formalin.

Results

TMJ injection of 1.5% formalin-induced inflammation in the form of significant (P<0.5) elevation of C-reactive protein and destruction of TMJ structure compared with the normal control group. Treatment with butorphanol decreased (P<0.05) the severity of formalin-induced TMJ inflammation and improved the histopathological TMJ structure.

Conclusion

The present results support that butorphanol tartrate has anti-inflammatory properties.

Related Topics

    loading  Loading Related Articles