The impact of butorphanol in rat temporomandibular joint inflammation


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Abstract

ObjectiveThe objective of the present study was to evaluate the anti-inflammatory effect of butorphanol in formalin-induced temporomandibular joint (TMJ) inflammation in rats.Materials and methodsA total of 30 adult male Wistar rats were randomly divided into three groups of 10 rats each – group 1, the saline control group: rats were subjected to TMJ injection of saline; group 2, the formalin control group: rats were subjected to TMJ injection of formalin and did not receive any treatment; group 3, the butorphanol-treated group: rats received TMJ injection of 0.4 mg/kg butorphanol 30 min after TMJ injection of formalin.ResultsTMJ injection of 1.5% formalin-induced inflammation in the form of significant (P<0.5) elevation of C-reactive protein and destruction of TMJ structure compared with the normal control group. Treatment with butorphanol decreased (P<0.05) the severity of formalin-induced TMJ inflammation and improved the histopathological TMJ structure.ConclusionThe present results support that butorphanol tartrate has anti-inflammatory properties.

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