Cardiac echoparameters (geometry and dimensions), interleukin 6, and anthropometric measurements in Egyptian adolescents with hepatitis C and hepatocellular carcinoma

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Abstract

Background

Hepatitis C virus (HCV) is the major risk factor of hepatocellular carcinoma (HCC) in all age groups. There is a need to differentiate between them in adolescence by laboratory and physical examination for the assessment of different outcomes of both diseases.

Patients and methods

The cross-sectional study included 30 adolescents with HCV, another 30 with HCC on top of previously known cirrhotic liver, and 20 healthy individuals served as control in the age range 12 up to 18 years (14.4±3.58). They were selected from those admitted to the National Hepatology and Tropical Medicine Research Institute Cairo, Egypt for laboratory interleukin 6 (IL-6) testing and further were examined at the Cardiology Unit in the Pediatric Department of Ain Shams University Hospitals for complete echocardiographic and anthropometric evaluation.

Results

Thirty patients having HCC were examined with mean age of 14.15±3.01 years and another 30 having HCV with a mean age of 14.64±4.13 years. The duration of HCC was 2.16±2.89 years, whereas the exposure to HCV was 2.27±3.35 years in the HCV group. Differences were found between both groups as regards IL-6 as the mean values were 0.26 pg/ml in HCV and 0.721 pg/ml in the HCC group, whereas no differences were detected as regards cardiac echoparameters (geometry and dimensions) and anthropometric evaluations.

Conclusion

IL-6 is a useful marker to compare between HCV and HCC in adolescent patients instead of depending on the evaluation of cardiac and growth complications that showed no differences.

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