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Bone mineral studies of children with autism are scanty.This cross sectional selective study aimed to compare bone mineral density (BMD) of autistic children to healthy children.39 autistic children were recruited from outpatient clinics of Special Needs Center of Postgraduate Childhood Studies, Ain-Shams University. Using DSM-IV all diagnosed autistic children were assessed for severity by Childhood Autism Rating Scale, examined for anthropometric data and was subjected for Serum Complete Blood Picture, Serum Calcium and Phosphorus levels. Laboratory investigations were investigated. All data compared to normal children.showed highly statistical significant difference in total BMD Z-score with P-value=0.001 and no significant difference in spine BMD Z-score P-value=0.255.The present study conclude that there is no relation between autism and BMD, for further evaluation of effect of diet restriction and drugs effect on BMD of autistic children.