The immunocytochemical characteristics of human gall bladder innervation

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Abstract

Objective

Various immunocytochemical characteristics of the human gall bladder innervation and epithelial secretor status were studied in an attempt to identify whether consistent changes might be found in gallstone formation and cholecystitis.

Results

No difference between normal and inflamed gall bladders were found in neuroendocrine, epithelial secretory and differentiation markers. A considerable reduction in the number of stainable nerve fibres and ganglion cells in the lamina propria was observed in inflamed gall bladders compared with normal. Whether this is a causal factor for abnormal gall bladder function or is merely a result of tissue damage has yet to be determined.

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