Does α1-antitrypsin phenotype PiMZ increase the risk of fibrosis in liver disease due to hepatitis C virus infection?

    loading  Checking for direct PDF access through Ovid

Abstract

Background

The factors influencing the development of hepatic fibrosis, a key factor in determining outcome, are incompletely understood in hepatitis C. It has been suggested that the heterozygous Z mutation of the α1-antitrypsin gene (PiMZ) predisposes to more severe liver damage when infected by the hepatitis C virus. This retrospective cross-sectional study was designed to compare the prevalence of PiMZ in hepatitis C patients with different degrees of fibrosis.

Patients and methods

One hundred and forty-one patients from the Trent Hepatitis C Study Group's database were selected for study. Forty-six had no fibrosis on liver biopsy, 53 had cirrhosis and 42 had intermediate fibrosis. The α1-antitrypsin phenotype was determined by isoelectric focusing.

Results

There was no significant difference between the prevalence of PiMZ in the three groups — there was just one patient in each group. Comparing those with no fibrosis with those with cirrhosis, the odds ratio was 0.87 (95% confidence interval, 0.05–14).

Conclusion

Our results do not support the hypothesis that the presence of the PiMZ phenotype predisposes to more severe fibrosis in patients with hepatitis C.

Related Topics

    loading  Loading Related Articles