Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis

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In the framework of the preclinical validation of the hypoxic tracer [18F]EF3, a comparison was performed between uptake of [18F]EF3 and EF5 adducts detected by immunofluorescence in MCa-4, FSA, FSAII, Sa-NH and NFSA tumour-bearing mice. Mice were allowed to breath carbogen (5% CO2, 95% O2), 21% oxygen or 10% oxygen. A significant correlation (r2=0.57; p<0.01) was found between the [18F]EF3 tumour-to-muscle ratio and the fluorescence intensity of EF5.

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