FDG uptake by the bone marrow in NSCLC patients is related to TGF-β but not to VEGF or G-CSF serum levels

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Abstract

Introduction

Non small cell lung carcinomas (NSCLC) are known to secrete various cytokines such as VEGF (vascular endothelial growth factor), G-CSF (granulocyte-colony stimulating factor) and TGF-β (transforming growth factor-beta) that may stimulate bone marrow activity.

Purpose

This study reports on the relationship between serum levels of VEGF, G-CSF, TGF-β and FDG uptake by the bone marrow in NSCLC patients.

Methods

Thirty-three patients suffering from newly diagnosed NSCLC who were successively referred to undergo an FDG PET scan as a part of their routine staging procedure and that did not suffer from bone metastases were included in the study. FDG bone marrow activity was determined in all patients and related to pre-treatment VEGF, G-CSF and TGF-β serum levels.

Results

Mean standardized uptake values (SUV mean) of the bone marrow ranged from 0.1 to 2.1 (mean 1.1). G-CSF, VEGF and TGF-β serum levels ranged from 13.5 to 110 pg/ml (mean 41.4 pg/ml), from 95 to 3,221 pg/ml (mean 1,111 pg/ml) and from 269 to 615 pg/ml (mean 387 pg/ml), respectively. SUV mean values of the bone marrow significantly correlated with TGF-β serum measurements (r = 0.621, p < 0.0001), but not with VEGF and G-CSF measurements.

Conclusion

FDG uptake by bone marrow in newly diagnosed NSCLC patients correlates with serum levels of TGF-β, but not with VEGF or G-CSF levels.

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