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To report a case of spontaneous combined resolution of vitreomacular traction (VMT) and pigment epithelial detachment (PED).A 70-year-old woman presented with a 10-day history of metamorphopsia in her right eye. Medical history was unremarkable. The patient underwent a complete ophthalmic examination. Best-corrected visual acuity (BCVA) was 20/50 in the right eye. Fundus examination, fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT) revealed a shallow elevated area with irregular edges suggestive of drusenoid avascular PED associated with VMT.During the follow-up, OCT showed combined resolution of VMT and PED with almost complete normalization of the outer retinal layers; BCVA increased to 20/40.The temporal sequence of events in our case strongly suggests that the spontaneous resolution of PED could be the consequence of or could be favorably influenced by the VMT resolution.