Granzyme B and perforin in lichen planus

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Abstract

Background

Lichen planus (LP) is an inflammatory dermatosis involving either skin and/or mucosal epithelial surfaces. The inflammatory infiltrate in LP is composed of variable proportions of CD4+ and CD8+ T lymphocytes. The formation of colloid bodies, also referred to as hyaline, cytoid, or civatte bodies, in the lower epidermis and upper dermis, is a characteristic histological feature of LP.

Objective

The aim of this study was to study the role of granzyme B and perforin in the pathogenesis and behavior of LP.

Patients and methods

A total of 27 LP patients were included in this study together with 27 normal controls. The patients and controls were subjected to complete history taking and general and dermatological examination; written informed consent was obtained from all patients. Punch skin biopsies were taken under local anesthesia and immunohistochemically stained for granzyme B and perforin expression.

Results

A statistically significant increase was seen in granzyme B and perforin expression in comparison with controls. A statistically significant increase was seen in granzyme and perforin expression with increase in the activity and intensity of the disease. No correlation was seen between granzyme B and perforin expression with the sex of patients, but there was a correlation between their expression and the age of the patients.

Conclusion

Increased granzyme B and perforin expression in LP lesions may suggest a possible role of granzyme B and perforin in the pathogenesis of LP and could be the target for future immunomodulator therapy.

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