Fatty acid synthase and hepsin expression in benign prostatic hyperplasia and prostatic carcinoma

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Abstract

Background

Prostatic carcinoma (PCa) is the sixth most common cancer and the second leading cause of death among men worldwide. Differentiating benign prostatic hyperplasia (BPH) from PCa can be challenging in some cases. The progression of prostate cancer is a multistep process and involves dysregulation of cell proliferation and death.

Materials and methods

This study was carried out on 82 cases, including 48 cases diagnosed as BPH and 34 cases diagnosed as PCa, received as paraffin blocks and fresh specimens.

Results

The immunohistochemical expression of fatty acid synthase was positive in the cytoplasm of three (6.25%) of 48 BPH cases and 32 (94.1%) of 34 PCa cases, with significantly higher expression in the higher Gleason scores (P<0.001). Hepsin expression was also investigated and was positive in eight (16.7%) of 48 BPH cases and in all cases of PCa, with increased expression in the higher Gleason scores (P<0.001).

Conclusion

These results showed that fatty acid synthase and hepsin overexpression, especially in high grades of PCa, makes them independent predictors of tumor progression and aggressiveness side by side with the diagnostic differentiation between benign and malignant prostates.

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