Expression of CD34 and D2-40 in different grades of mucoepidermoid carcinoma

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Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm characterized by proliferation of epidermoid, mucous, and intermediate cells in various proportions. This study was carried out to evaluate the immunohistochemical expression of CD34 and D2-40, as markers of angiogenesis and lymphangiogenesis, in MEC and their correlation with the tumor grade and stage.

Materials and methods

A total of 21 salivary gland MEC tissue samples were collected. Age, sex, site, stage, and histologic grades were reviewed. The samples were immunohistochemically stained with monoclonal antibodies against CD34 and D2-40.


A strong positive cytoplasmic immunostaining of CD34 and D2-40 antibodies was revealed in all cases of high-grade MEC, whereas mild to moderate positive immunohistochemical staining of both markers was demonstrated in the low-grade specimen of MEC with significant relation to tumor grade or stage.


Microvessel density and lymph vessel density obtained immunohistochemically were associated with tumor grade or stage. Thus, a direct correlation between the histological grade or tumor stage of MEC and angiogenesis or lymphangiogenesis has been suggested.

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