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Evaluation of hypoxia-inducible factor-1α (HIF-1α) immunohistochemical expression in colorectal carcinoma (CRC) and correlation of its expression with various clinicopathological parameters.This retrospective study was conducted on 45 cases of CRC, including 35 (77.8%) cases with adenocarcinoma and 10 (22.2%) cases with mucinous carcinoma (defined as tumors showing extracellular mucinous pools in ≥50% of the tumor tissue). A total score of HIF-1α expression was obtained by multiplying the score of staining intensity and score of the percentage of positively stained cells to obtain a score ranging from 0 up to 12.Positive HIF-1α expression was detected in 26 (57.8%) cases. There were significant correlations between HIF-1α expression and tumor invasiveness (T) (P=0.034) and modified Dukes’ classification (P=0.049). Higher frequency of HIF-1α expression was associated with the presence of lymph-node metastasis and the presence of lymphovascular emboli but with no statistically significant correlation. There was no significant correlation between HIF-1α expression and age, sex, size, site, histological type, histological grade, or perineural invasion among the studied cases.HIF-1α immunohistochemical expression is significantly correlated with tumor invasiveness (T) and modified Dukes’ classification that suggests the possible role of HIF-1α in tumor invasion, metastasis, and as a prognostic marker for prediction of the behavior of CRC cases.