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Meningiomas are considered the second most common primary intracranial tumors. Biological behavior of meningiomas varies significantly. Not only histopathological features determine the behavior but also the surgical grade of resection which determines the disease-free survival in patients with histologically similar types. The aim of this study was to investigate the epidermal growth factor receptor (EGFR) and proliferating cell nuclear antigen (PCNA) expression in different histopathologic grades of meningiomas.This study included 51 cases of meningiomas classified as follows: 30 cases benign, 11 atypical, and 10 cases of anaplastic meningiomas. Immunohistochemical staining of all cases using EGFR and PCNA antibodies was done.There were significant decreases in the percentage score, intensity score, and immunoreactivity scores of EGFR expression from benign through atypical to anaplastic meningiomas. There was a significant increase in the mean percentage of the PCNA proliferating index with increasing grades of meningiomas from benign through atypical to anaplastic meningiomas.EGFR expression is decreased with increasing grades of meningiomas so it can be used as a prognostic marker or used in clinical treatment. Also, detection of PCNA proliferating index is an essential diagnostic tool for the diagnosis of high-grade meningiomas and also can be used as a predicting marker for bad prognosis.