Evaluation of the role of HIF-1α and GLUT-1 in the pathogenesis of ovarian surface epithelial tumors and their prognostic impact

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Abstract

Objective

The study aims to evaluate the role of HIF-1α and GLUT-1 expressions in the pathogenesis of ovarian surface epithelial tumors and their prognostic impact.

Background

Ovarian carcinoma is the most lethal gynecological malignancy. Although many surgical techniques and chemotherapies have been developed, the prognosis remains poor, with a 5-year survival rate of 45%.

Patients and methods

This retrospective study included 89 surface epithelial ovarian tumors from Egyptian patients, including 16 cases of benign tumors (cystadenoma), 19 cases of borderline tumors, and 54 cases of malignant tumors. The malignant group was divided into types I and II for comparison. Immunohistochemical staining for HIF-1α and GLUT-1 was performed and their expression was correlated with the clinicopathological features of prognostic importance.

Results

HIF-1α was significantly expressed in borderline and malignant groups as compared with benign groups (P<0.001). The H-score of GLUT-1 immunostaining showed a gradual increase from benign to borderline to malignant groups (P=0.000). A significant association was found between GLUT-1 expression and tumor bilaterality (P=0.004), solid or mixed cut section (P=0.03), presence of vascular invasion (P=0.05), presence of gross and microscopic omental nodules (P=0.003 and 0.001), T3 stage (P=0.01), and FIGO stage III (P=0.01) which indicate poor prognosis.

Conclusion

HIF-1α and GLUT-1 may play a significant role in the carcinogenesis and progression of ovarian carcinomas.

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