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Prostate cancer (PCa) is cancer that varies in its behavior. Identifying the expression of genes involved in the pathogenesis can help in predicting its prognosis.The aim was to study the expression of erythroblast transformation-specific-related gene (ERG), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and fatty acid synthase (FASN) in localized PCa and their prognostic value.Immunohistochemical analyses of ERG, PTEN, and FASN on PCa specimens were performed to evaluate their expression and correlation to variable clinicopathologic parameters.Overexpression of ERG and FASN as well as PTEN loss were significantly associated with high prostate-specific antigen level (P=0.010, 0.000, .000, respectively), Gleason score greater than 7 (P=0.000, 0.000, 0.004, respectively), advanced tumor stage (P=0.022, 0.002, 0.008, respectively), biochemical recurrence (P=0.000, 0.018, 0.005, respectively), and shorter recurrence-free survival (P=0.021, 0.000, 0.009, respectively). PTEN loss was significantly correlated with both high ERG and high FASN expression (P=0.017, 0.000, respectively) without any detectable association between ERG and FASN (P=0.773). PTEN loss was the independent predictor of biochemical recurrence in multivariate analysis (P=0.006).Evaluation of PTEN in biopsies of patients with localized PCa can predict high-risk patients of biochemical recurrence.