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The aim of the study was to evaluate and compare the sealing quality of hand- or vacuum-obturated root canals after hand instrumentation or noninstrumentation cleansing. A total of 60 single-rooted teeth were divided into six comparable groups. The root canals of three groups were instrumented with the balanced-force technique and obturated with gutta-percha condensation. The remaining teeth were cleansed and filled using noninstrumentation technology and the same sealers as with hand instrumentation (AH Plus, Apexit, Pulp canal sealer EWT). After aging the quality of coronal seal was assessed with a dye penetration method after perfusion with the dye under vacuum. The results of this study indicated superior sealing of the machine-filled roots (noninstrumentation technology), compared with laterally condensed conventionally filled root canals.