Periodontal regeneration: experimental observations—clinical consequences

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Biologic evidence thus far points to the presence of cells originating from the periodontal ligament, wound stability, space-provision, and primary intention healing as central biologic and clinical factors that must be afforded to a site to obtain periodontal regeneration. Only profound appreciation of these biological and clinical variables affecting the outcome of periodontal regenerative procedures will allow clinicians to proficiently manipulate them to optimize the clinical result and elevate predictability of periodontal regenerative therapy.

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