ThedddPgene, encoding a novel enzyme that converts dimethylsulfoniopropionate into dimethyl sulfide, is widespread in ocean metagenomes and marine bacteria and also occurs in some Ascomycete fungi


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Abstract

SummaryThe marine alphaproteobacteriumRoseovarius nubinhibensISM can produce the gas dimethyl sulfide (DMS) from dimethylsulfoniopropionate (DMSP), a widespread secondary metabolite that occurs in many phytoplankton.Roseovariuspossesses a novel gene, termeddddP,which when cloned, confers onEscherichia colithe ability to produce DMS. The DddP polypeptide is in the large family of M24 metallopeptidases and is wholly different from two other enzymes, DddD and DddL, which were previously shown to generate DMS from dimethylsulfoniopropionate. Close homologues of DddP occur in other alphaproteobacteria and more surprisingly, in some Ascomycete fungi. These were the biotechnologically importantAspergillus oryzaeand the plant pathogen,Fusarium graminearum. ThedddPgene is abundant in the bacterial metagenomic sequences in the Global Ocean Sampling Expedition. Thus,dddPhas several novel features and is widely dispersed, both taxonomically and geographically.

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