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Vibrio splendidusis a dominantVibriospecies in seawater presenting a remarkable genetic diversity; several strains have been linked to invertebrate's mortality. We report the complete genome sequence ofV. splendidusLGP32, an oyster pathogen, and its comparison with partial genome sequences from related strains. As is typical for the genus,V. splendidusLGP32 contains two chromosomes (3.29 and 1.67 Mb) and most essential cellular processes are encoded by chromosome 1. Comparison with two otherV. splendiduspartial genome sequences (strains 12B01 and Med222) confirms the previously suggested high genotypic diversity within this species and led to the identification of numerous strain-specific regions that could frequently not be assigned to a specific mechanisms of recombination. Surprisingly, the chromosomal integron, the most variable genetic element in all otherVibriospecies analysed to date, is absent from 12B01 and inactivated by a mobile element in Med222, while in LGP32 it only contains a limited number of cassettes. Finally, we found that the LGP32 integron contains a newdfrAcassette, related to those found in resistance integrons of Gram-negative clinical isolates. Those results suggest that marineVibriocan be a source of antibiotic resistance genes.