THE RELATION OF DOCUMENTED CORONARY ARTERY DISEASE TO LEVELS OF TOTAL CHOLESTEROL AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL

    loading  Checking for direct PDF access through Ovid

Abstract

Recommendations for identifying persons at high risk for coronary heart disease are based primarily on levels of total and low-density lipoprotein cholesterol. We examined whether, given knowledge of these levels, information on the high-density lipoprotein cholesterol level would improve the prediction of arteriographically documented coronary artery disease among 591 men. We found that even at levels of total and low-density lipoprotein cholesterol considered desirable, high-density lipoprotein cholesterol was inversely related to disease severity. For example, among the 112 men with a total cholesterol level <180 mg per dl, the mean occlusion score (representing the overall severity of disease) was 107 among men with a high-density lipoprotein cholesterol level ≤30 mg per dl vs a mean score of 52 among men with levels ≥45 mg per dl. Furthermore, men with low levels of both low-density lipoprotein cholesterol (<110 mg per dl) and high-density lipoprotein cholesterol (≤30 mg per dl) had as much occlusive disease as did men with high levels of both lipoprotein fractions. Given information on the ratio of high-density lipoprotein cholesterol to total cholesterol, the actual levels of the lipoprotein fractions did not improve disease prediction. Our results emphasize the importance of considering high-density lipoprotein cholesterol when assessing coronary heart disease risk.

Related Topics

    loading  Loading Related Articles