Glucose Utilization During Interictal Intervals in an Epilepsy Model Induced by Pilocarpine: A Qualitative Study

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Abstract

Purpose:

Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. In our research, a [14C]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.

Methods:

Epileptic rats were monitored by video-EEG for ∼120 days, with [14C]2DG injected after a seizure-free interval of ≥24 h.

Results:

Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and pretectal region.

Conclusions:

These findings suggest that the lateral posterior thalamic nucleus and the pretectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.

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