Seizures following picornavirus infection

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Abstract

Purpose

We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice.

Methods

C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-β expression).

Results

C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-β expression correlate with seizure activity in the hippocampus.

Discussion

The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans.

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