CHEUNG, S. S., and G. G. SLEIVERT. Multiple triggers for hyperthermic fatigue and exhaustion. Exerc. Sport Sci. Rev., Vol. 32, No. 3, pp. 100–106, 2004. It has been proposed that a critical body temperature exists at which muscle activation is impaired through a direct effect of high brain temperature decreasing the central drive to exercise, but other factors may also inhibit performance in the heat. An integrative physiological model is presented to stimulate research into mechanisms of hyperthermic fatigue and exhaustion.