Posttranslational Arginylation Regulates Striated Muscle Function

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In this article, we propose the hypothesis that the posttranslational arginylation of proteins, a process catalyzed by the enzyme arginyl-tRNA-transferase, regulates active and passive force generation in striated muscles. Specifically, we propose that proteins essential for muscle contraction and force production are regulated by arginylation, including myosin heavy chain, troponin, actin, and titin filaments.

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