Sympathetic Vasoconstriction in Skeletal Muscle: Adaptations to Exercise Training

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Sympathetic vasoconstriction in the skeletal muscle vascular bed is essential for the regulation of vascular resistance and therefore control of blood pressure and muscle blood flow at rest and during exercise. In this article, we address the hypothesis that aerobic exercise training alters sympathetic vasoconstrictor responsiveness and enhances contraction-mediated inhibition of sympathetic vasoconstriction (functional sympatholysis) through a nitric oxide–dependent mechanism.

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