Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue

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Muscle fatigue can result from either the accumulation of metabolic by-products (e.g., Pi and H+) or a decrease in myoplasmic Ca++; however, individually, neither change can explain quantitatively the decrease in force capacity. Therefore, the emerging view is that, by decreasing the sensitivity of myofilaments to calcium, Pi and H+ act synergistically with decreased Ca++ levels to contribute to fatigue.

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