Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs

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In guinea pigs, we found that intravenous 5,8,11,14-eicosatetraenamide (N-2-hydroxyethyl), arachidonylethanolamide (anandamide), 0.3–10.0 mg/kg, did not inhibit leukotriene D4 (LTD4)-induced airway obstruction, while inhaled anandamide, 21.8 and 43.6 μg/kg (estimated inhaled doses), significantly reduced this airway obstructive effect by 24.8 ± 8.8 and 42.0 ± 11.2%, respectively. In contrast, aerosolized anandamide (43.6 μg/kg) was ineffective against histamine-induced bronchoconstriction. Thus, inhaled, but not intravenous anandamide selectively antagonizes the bronchospasm produced by LTD4.

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