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Purpose: The aim of our study was to define clinical and echocardiographic parameters which impacted left ventricular (LV) function and structure in patients with systemic sclerosis (SSc).Methods: Study included 55 SSc patients and 50 healthy volunteers adjusted by age and sex. All subjects underwent clinical examination, pulmonary function testing, and complete two-dimensional echocardiography which included pulsed and tissue Doppler. We determined the ratio of early diastolic transmitral and septal area of the mitral annulus flow velocities (E/e'septal). LV global ventricular function was estimated by the Tei index. Pulmonary vascular resistance (PRV) was calculated by using echocardiographic parameters.Results: Pulmonary hypertension was presented in 38 patients (69%). Multiple regression analysis showed that diffusion capacity for carbon monoxide (DLCO) (β=0.515, p<0.001), PRV (β=0.451, p<0.001), tricuspid (e'/a')septal (β=-0.354, p=0.016) and E/e'septal ratio (β=0.602, p<0.001), and RV Tei index (β=0.541, p<0.001) were independently associated with mitral E/e'septal. Multivariate analysis revealed that DLCO (β=0.511, p<0.001), PRV (β=0.392, p=0.031), and the RV Tei index (β=0.634, p<0.001) were independently associated with the LV Tei index. Analysis of results showed that LV mass index was independently associated with PRV (β=0.367, p=0.016), RV systolic pressure (β=0.551, p<0.001), and RV Tei index (β=0.317, p=0.025).Conclusion: Our study revealed some new non-invasive parameters which are useful for everyday clinical practice for determination of early involvement of the left ventricle in SSc.