P1038Ascending aortic distensibility, stiffness index beta and tissue Doppler-based wall strain in bicuspid aortic valve patients

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Purpose: Recently tissue Doppler-based strain (TDS) of the aortic wall was used for the assessment of elastic aortic properties. We evaluated aortic elasticity by conventional formulas and related them to aortic TDS in bicuspid aortic valve(BAV).Methods: The study group consisted of 85 patients with BAV.Conventional formulas for aortic elasticity were:aortic distensibility(DIS)=2x(SD–DD)/[(SBP–DBP)xDD][cm2×dyne(-1)×10(-6)]and aortic stiffness index(β)(SI)=ln(SBP/DBP)/[(SD–DD)/DD][-]where SD,DD and SBP,DBP are systolic and diastolic mid-ascending aortic diameters and blood pressures,respectively.Maximal systolic TDS[%]of the mid-ascending anterior aortic wall was calculated. Independent predictors of DIS,SI and TDS were found by multiple linear regression analysis. Variables included:age, gender,weight,systolic blood pressure(SBP),BAV cusp fusion patterns(right-noncoronary or right-left fusion),LVEF,ascending aortic diameter,and the severity of aortic stenosis and regurgitation.Results: Mean values of measured parameters were:TDS=16.5±6.3%,SI=10.1±6.02,DIS=2.60 ± 1.76 cm2xdyne(-1)x10(-6).There is no correlation between TDS, SI and DIS. Significant predictors of studied indexes are presented in table.Conclusions: Tissue Doppler-based aortic wall strain is independent of conventional measures of aortic elasticity and is associated with the severity of aortic valve disease and thus could be used for the evaluation of aortic hemodynamic stress caused by bicuspid aortic valve.

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