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Introduction: The mechanical properties of common carotid artery have been introduced as risk factors of cardiovascular disease. Base on speckle tracking, we are able to access multi-dimensional mechanics such as strain, strain rate, and displacement of myocardium and even vessels. However, the clinical significance of arterial properties defined determined by speckle tracking remained unknown. We therefore investigated their associations with conventional arterial stiffness parameters in a population with heart failure (HF).Methods: A total of 75 subjects was recruited, and 21 patients presented with HF. Central blood pressures, carotid-femoral pulse wave velocity (cf-PWV), carotid augmentation index (cAI), augmented pressure (Pa), forward (Pf) and backward (Pb) pressure waves amplitude as well as left ventricular ejection fraction (LVEF), and common carotid artery circumferential strain (CAcS) and radial speckle strain (CArS) were measured.Results: The mean intra-observer and inter-observer agreements were 99.93±0.8% and 99.91±0.1% for CAcS, and 99.8±0.4% for CArS. CAcS was significantly associated with LVEF (r=0.298), cPP (r=0.387), Pi (r=0.354), Pf (r=0.435), and Pb (r=0.413), but not cf-PWV or cAI. CArS significantly correlated with LVEF (r=0.250) but not cAI, cPP, cf-PWV or Pb. In addition to BMI and pulse rate increased in HF, both CAcS and CArS reduced significantly in HF then those without HF. After accounting for cPP, cf-PWV or cAI, both CAcS (odds ration 0.49) and CArS (odds ration 0.092) remained associated with HF. The ROC curves in predicting HF were comparative with cAI, cPP and cf-PWV.(Figure)Conclusions: Mechanical properties of carotid artery accessed by speckle tracking were associated with conventional arterial stiffness parameters, and were also independently related to HF.