P1053Comparison of carotid Doppler echo-tracking and central aortic stiffness parameters in patients with preserved systolic function

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Background: Central aortic stiffness parameters (PWVao) are commonly used to determine the development of atherosclerotic disease. Carotid stiffness may be of particular interest, since in that artery atherosclerosis is frequent particularly in patients with verified CAD.Aim: The aim of our study was to compare central and local arterial functional parameters measured by two different non-invasive methods in patients with verified coronary artery disease (CAD) who exhibited preserved left ventricular systolic function (53±8%). Furthermore, we compared and contrasted these stiffness parameters to the coronary SYNTAX Score in patients who underwent coronary angiography.Methods: In our study 186 CAD patients were involved and similar non-invasive measurements were performed in 186 healthy subjects. Central aortic pulse wave velocity (PWVao) and augmentation index (AIXao) were measured by a novel oscillometric device, the Arteriograph, and the common carotid artery was studied by Doppler echo-tracking system to determine the local PWVcar and AIXcar. Left ventricular ejection fraction was determined by Aloka ProSound 5500 Doppler echocardiograph according to Simpson's method.Results: In the CAD group the PWVao and AIXao values increased significantly (10.2±2.3 m/s and 34.5±14.7%) compared to control group (9.5±1.5 m/s and 30.2±12.8%; p<0.05). We observed similar significant increase in the local stiffness parameters (PWVcar and AIXcar) in CAD group. Furthermore, we found strong correlation for PWV and AIX values which were measured with the Arteriograph and those obtained using echo-tracking method (r=0.57; p<0.001 for PWV, and r=0.65; p<0.001 for AIX values).Conclusion: Our results suggest that the increased cardiovascular risk could be assessed by the similar extent with the local, and central arterial stiffness parameters in patients with verified CAD.

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