P261Assessment of left atrial volume in hypertension with and without left ventricle hypertrophy

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Objectives: This study was designed to identify an association between left atrial volume index (LAVi) and hypertension (HTN) with or without left ventricle hypertrophy (LVH).Background: Left atrial enlargement has been suggested as a robust marker of cardiovascular disease. However, the association between atrial enlargement and hypertension was not clearly defined.Methods: A cross-sectional sample of 60 HTN patients <60 years of age underwent comprehensive Doppler echocardiography in Departement of Cardiology and Vascular Medicine, Faculty of Medicine, University. All patients with normal LV systolic function were grouped according to the presence of HTN with and without LVH. Left atrial volume was assessed with Biplane-Area length method from four-chamber and 2-chamber views, and indexed to body surface area. The measurement of diastolic function was done according to Recommendations of European A Society of Echocardiography.Results: Of 46 patients included, 23 with LVH and 23 without LVH. There were no significant different in clinical characteristic ( age, gender, body surface area (BSA), blood pressure) between the two group. Left ventricular mass index (LVMi ) in HTN group with LVH was 129,80 ± 26,03 gram/m2 and significantly different (p<0,001) compare to HTN group without LVH (89,49 ± 16,70 gram/m2), HTN group with LVH had LAVi 33,34± 9,23 ml/m2 while in HTN non LVH 26,05 ± 6,76 ml/m2 ( p 0,004). LVMi grade was positively associated with LAVi ( r=0,30; p 0,04). Proportion of diastolic dysfunction was higher in LVH group compare those non LVH (86% vs 47%;p<0,005).Conclusions The larger LAVi was observed in HTN with LVH compare to those who had no LVH. It apparently due to higher proportion of diastolic dysfunction in HTN with LVH. This study suggest the importance of LAVi assessment in patients with hypertension.

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