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Background: Little is known on the acute impact of single alcohol consumption on myocardial function.Methods: We studied 19 party guests by high-end ultrasound-scanners before and 16-18 hours after alcohol consumption. 5 individuals served as controls. Population and echocardiographic parameters were analysed blindedly.Results: Baseline data of controls and alcohol-consumers were comparable. Body-weight and vital signs remained unchanged at the second visit. In the alcohol consumption group, peak-blood alcohol-concentration was 1.4±0.4 g/kg without gender differences (p=0.6). Diastolic function was impaired (E/A-ratio: 1.7±0.4 vs. 1.6±0.4, p=0.02). Systolic LV-function was reduced (EF 58±8 vs. 52±6, p<0.001 and GS -22.9±2.9 vs. -19.2±3.2%, p<0.001). GS-reduction correlated with peak alcohol concentration (r=-0.7, p=0.002).Conclusion: By means of echocardiography we observed for the first time a dose-dependent depression of left ventricular function after single acute alcohol consumption. Further studies are warranted to elucidate the clinical relevance of this effect in patients with impaired left ventricular function.