P322Systemic lupus erythematosus: impact of myocardial strain evaluated by speckle tracking

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Systemic lupus erythematosus (SLE) may be associated with pulmonary hypertension and left ventricular dysfunction, which have clinical impact.The purpose of this study was to evaluate myocardial deformation using speckle tracking echocardiogram in patients with SLE and normal left ventricle ejection fraction (LV EF), for the detection of earlier ventricular function disturbances when LV EF is still normal.Methods: 55 (consecutive) patients with SLE (39 ± 4 years; 50 female) were studied. Patients with LV EF <55%, hypertension, ischemic or valvular heart disease were excluded. A control group was composed by 17 healthy subjects (37 ± 4 years; 13 females). The parameters analyzed in both groups were: global systolic strain and strain rate (two-chamber, four-chamber and short-axis), left atrium volumes and ejection fraction, E/E 'mitral and Tei index.Results: The quality of image was adequate to the study by speckle-tracking in most studies, rejecting readings in <1% of the segments. Compared with the control group, volumes and LV EF of patients with SLE did not differed significantly, as well as left atrium volumes and ejection fraction and global systolic strain. Patients with SLE showed significantly lower global strain rate than the control group (-0.97 + / -0.20 vs -1.14 + / -0.17, p = 0.01), and also significantly increased Tei index (00:40 ± 0:11 vs 0:31 ± 0.03, p = 0.01).Conclusion: Myocardial deformation assessed by speckle tracking and Tei index may detect early cardiac involvement in patients with SLE and normal LV EF. Clinical and prognostic impact of these findings should be examined in future studies

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