P346A novel mathematical based software for modeling the left ventricular myocardium

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Purpose: Currently, an echocardiogram presents the left ventricle (LV) based on images obtained from ultrasound methods. Utilizing mathematical equations, specific echocardiographic data may provide more detailed, valuable and practical information for physicians. In our project using appropriate mathematically based softwares, we have attempted to create a novel software capable of demonstrating LV model in normal hearts.Methods: Echocardiography was performed on 70 healthy volunteers. Data evaluated included: velocity (radial, longitudinal, rotational and vector point), displacement (longitudinal and rotational), strain rate (longitudinal and circumferential) and strain (radial, longitudinal and circumferential) of all 16 LV myocardial segments. Using these data, force vectors of myocardial samples were estimated by MATLAB and LSDYNA softwares. Dynamic orientation contraction (through the cardiac cycle) of every individual myocardial fiber could be created by adding together the sequential steps of the multiple fragmented sectors of that fiber. This way we attempted to mechanically illustrate the global LV model.Results: LV Myocardial modeling: Our study shows that in normal cases myocardial fibers initiate from the posterior-basal region of the heart, continues through the LV free wall, reaches the septum, loops around the apex, ascends, and ends at the superior-anterior edge of LV.Conclusion: We were able to define the whole LV myocardial model mathematically based on echocardiography, by MATLAB software and LSDYNA software in normal subjects. This will enable physicians to diagnose and follow-up many cardiac diseases when this software is interfaced within echocardiographic machines.

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