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Background: Speckle tracking measurement of left atrial (LA) strain ([Latin Small Letter Open E]) allows evaluation of contractile, reservoir, and conduit function. We sought to compare LA [Latin Small Letter Open E] with velocity vector imaging (VVI) and two-dimensional strain (2DS).Methods: LA [Latin Small Letter Open E] and strain rate (SR) were compared in 141 patients (62+/-10 years) using both VVI and 2DS. Peak negative, peak positive, and total [Latin Small Letter Open E] (corresponding to LA contractile, conduit, and reservoir function) were measured during sinus rhythm. Late negative SR (LA contraction), peak positive SR (LV systole), and early negative SR (LV early diastole) were identified during sinus rhythm.Results: LA [Latin Small Letter Open E] measurement was highly feasible with both VVI (93%) and 2DS (93%). Peak negative, positive and total [Latin Small Letter Open E] correlated well (r=0.78, 0.75, 0.79), with low mean differences (Figure and Table). LA contraction, peak positive and negative SR correlated less well (r=0.74, 0.7, 0.67) with higher mean differences (Table).Conclusion: Left atrial [Latin Small Letter Open E] measurement is feasible with both VVI and 2DS in clinical practice. LA [Latin Small Letter Open E] and SR measurements using VVI showed quite similar results with 2DS.