P369Elevated systolic blood pressure from the age of 36 years onwards can predict left ventricular mass at ages 60-64 years independent of sex and treatment for hypertension (The MRC NSHD)

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Introduction: Cross-sectional elevated systolic blood pressure (SBP) is associated with increased left ventricular mass (LVM) which leads to increased cardiovascular morbidity and mortality. The association between SBP and LVM may vary by sex as men and women have different SBP trends across the life course.Methods: This study is a birth cohort study following all singleton men and women born in Britain in the first week of March 1946. 1700 participants underwent echocardiography (Vivid I, GE) in the current round of data collection (2006-2011) aged 60-64 y. LVM was measured and indexed to body-surface-area (LVMI) as per ASE guidelines. The relationship between current SBP and previous SBP (measured at 53, 43 and 36 y) with LVMI was investigated for each sex using separate linear regression models.Results: Increasing SBP at all ages was associated with increasing LVMI (see table). The strongest relationship between LVMI and SBP was with SBP at 53 years in both sexes. There was no evidence of a sex-difference between LVMI and SBP at any age, and the findings did not change when hypertension treatment was included in the model (not shown).Conclusions: Higher SBP measured from 36 years onwards predicts a greater LVMI, independent of sex and hypertension treatment. Individuals with high SBP in early adulthood should be identified and appropriate antihypertensive treatment initiated to prevent subsequent increased LVMI and its complications.

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