P378Global deformation from infancy to adulthood - are there differences?

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Purpose: To assess the influence of age, weight, body surface area, sex, heart rate (HR) and LV-length on global LV systolic defor-mation.Methods: 158 healthy children and young adults (78f, 80m, 0-20y, median 9,6y) were investigated using 2D-Strain speckle tracking (Vivid 7, GE, Echopac). Due to prior tests for reproducibility of results only global longitudinal (GL), circumferential (GC) Strain(S)/Strain-Rate (Sr) and maximal torsion/cm (Tormax) were investigated. Statistical analysis by T-Test, Pearson`s coefficient of correlation and creation of percentiles using the LMS method.Results: GCS (f: -16.6±3.7%, m: -16.8±4%) and Tormax (f: 2.6±1.7°/cm, m: 2.9±2.1°/cm) correlated negatively with age (r=-0.22, p<0.05 and r= 0.67, p<0.01) and weight (r=-0.19, p<0.05 and r=-0.62, p<0.01), GLS (m: -18.8±3.1%, f: -20.4±2.9%) did not change significantly. Differences between sex were found for GLS (p<0.01). GLSr correlated with age (r=0.57, p<0.01), weight (r=0.55, p<0.01), BSA (r=0.23, p<0.05) and LV-length (r=0.58, p<0.01). HR correlated with Tormax (r=0.65, p<0.01), GLS (r=0.22, p<0.01) and GLSr (r=-0.56, p<0.01).Conclusions: The complex LV motion shows changes during maturation from predominant rotation influenced by HR in infancy to quicker deformation with higher GLSr in adulthood and constant GLS over all age groups.

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