P386Relationship between gamma-glutamyl transferase and epicardial adipose tissue in patients with coronary artery disease


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Abstract

Objectives: Epicardial adipose tissue (EAT) is thought to be related to the presence and severity of coronary artery disease. Gamma-glutamyltransferase (GGT) levels were found to be strongly associated with cardiovascular risk factors and a direct link between increased GGT activity and occurrence and progression of atherosclerosis is suggested. In this study, we aim to investigate the relationship between EAT and serum GGT levels in addition to common cardiovascular risk factors in patients with stable coronary artery disease (CAD).Methods: One hundred twenty consecutive patients who underwent coronary angiography for stable anginal symptoms were included. EAT thickness was measured using 2-dimensional echocardiography from the free wall of right ventricle in the parasternal long-axis view. Laboratory parameters including serum GGT levels were measured from fasting blood samples before cardiac catheterization.Results: Of the 120 patients, 83 were found to have significant coronary artery disease (Defined as at least ≥50% narrowing in one coronary artery). EAT thickness and serum GGT levels were significantly higher in patients with CAD as compared to those without CAD (p = 0.006, p=0.04, respectively). In all group, GGT was found to be moderately but significantly correlated with the EAT value (r=0.37, p<0.001). In the logistic regression analysis, taking the previously determined EAT cut-off value as the dependent variable, GGT, waist circumference and serum fasting glucose levels were found to be independent predictors of EAT cut–off value (95 % CI: 0.02-0.08, p=0.003; 95% CI 0.03-0.09, p <0.001; 95 % CI 0.003- 0.03, p= 0.015 respectively).Conclusion: Our findings demonstrated that in patients with stable CAD, echocardiographic EAT was significantly higher as compared with those without CAD. Also, serum GGT levels was significantly correlated with EAT.

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