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Background: Behcet' s disease (BD) is a chronic inflammatory disease characterized by recurrent oral and genital ulcerations and ocular lesions. This multisystemic disorder mostly affects the vascular system. In the present study we aimed to evaluate vascular endothelial function in patients with Behcet' s disease without vascular involvement.Methods : We studied 40 patients with BD ( 44.9±5.4 years and 59% male) and 30 healthy controls (45.4± 8.2 years and 60% male) . Brachial artery Doppler ultrasonography (USG) and bilateral carotid artery intima-media thickness measurements were performed.Results: Basal diameter and nitrate induced dilation (NID) of the brachial artery were similar between the two groups. However, flow-mediated dilation (FMD) was markedly impaired in patients with Behcet' s disease. (Table 1). Carotid artery intima-media thickness was slightly increased in the patient group, compared to the control group; but it did not reach significance (0.69±.15 to 0.59±0.09 respectively; p=0.06).Conclusions: Vascular endothelial function, which can be attributed to premature atherosclerosis is impaired in Behcet disease. Brachial artery Doppler USG is a reliable method to reveal changes in endothelial function.