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The aim of the present study was to evaluate the dynamics of left ventricular (LV) longitudinal function by 2D strain imaging during squatting in patients with coronary artery disease (CAD).Methods: We examined 53 consecutive men (age 53.02±0.95 years) with indications for coronary angiography (CA). Based on the results of CA patients were divided into 2 groups: the first group without CAD (n=18) and the second group with CAD (n=35). During squatting the peak septal annular displacement (TMAD1) (mm) and peak lateral annular displacement (TMAD2) (mm) were assessed by 2D strain echocardiography.Results: In the first group at the baseline the TMAD1 and TMAD2 were significantly higher in the lying position (12.07±1.13 mm and 9.86±0.66 mm, p=0.03; 12.17±0.89 mm and 9.52±0.51 mm, p=0.007, respectively) and in the squatting (10.70±0.96 mm and 6.92±0.72 mm, p=0.002; 10.94±0.89 mm and 7.43±0.88 mm, p=0.03, respectively). In the squatting TMAD1 and TMAD2 decreased significantly only in the second group (p=0.001 and p=0.008, respectively).Conclusion: 2D strain echocardiography revealed impairment of LV longitudinal function in patients with CAD during squatting. Probably, assessment of LV longitudinal function by 2D strain echocardiography can be used for the screening of CAD patients during squatting stress.