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Introduction: It is known that left atrial remodeling after acute myocardial infarction (AMI) is an independent prognostic factor of mortality. Recently it was suggested the evaluation of atrial function with two-dimensional strain by speckle tracking (2DS).Aim of the study: To assess the modifications of left atrial function (contraction and relaxation) in patients with first promptly revascularized AMI.Materials and methods: Consecutive patients were submitted to echocardiogram at discharge. The left atrial function, with 2SD, was assessed by determination of all peak strain (S) and strain rate (Sr) for analyzing the components of relaxation, passive and contractile. Clinical follow-up to 12 months. The data of the population with AMI (Group I) were compared with a healthy control population (Group C).Results: We enrolled 59 patients (48M), mean age 62.58±11.64 years. Group C consists of 11 healthy subjects. The comparison of the two groups showed significant differences in all indexes of atrial function of S and SR (Table). The headquarters of the AMI did not affect significantly the atrial function and ventricular systolic dysfunction (P<0.05 for all). In particular, the magnitude and extent of the dysfunctional, as assessed by WMSI, correlated significantly with atrial function (R= -0.56, P<0.001). Finally, patients with events at follow-up of 12 months (death, heart failure and clinical driven revascularization) had more compromised baseline atrial function (Table).Conclusions: In AMI left atrial function is compromised in both contraction and relaxation. The changes of left atrial function were significantly higher in patients with more pronounced left ventricular dysfunction. Patients with events at follow-up have higher changes in atrial function.