P454Influence of ageing on tricuspid flow propagation velocity in a healthy subjects.

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Early tricuspid flow propagation velocity (FPV) has clinical significance, given its relationship with systolic pulmonary artery pressure and exercise tolerance. However, knowledge about age-related changes of this index in healthy subjects is very limited.The aim of this study was to determine age changes of the tricuspid flow propagation velocity in healthy subjects.Material and methods: The study included 270 healthy volunteers 13–83 years old (M/F = 129/141) without cardiovascular and respiratory diseases and pathology changes at the ECG. The population was divided in seven age decades: 14-20 (n=22), 20-29 (n=32), 30-39 (n=38), 40-49 (n=54), 50-59 (n=81), 60-69 (n=27), and >70 years (n=16). All participants in the combined color M-mode was measured tricuspid flow propagation velocity in the cavity of the right ventricle by measuring the slope of the line early diastolic wave colored Doppler spectrum. In addition, the indicators studied pulsed-wave Doppler tricuspid flow - early tricuspid flow velocity (E), the flow velocity of atrial systole (A) and E/A ratio.Results: (See table). There was a significant decrease in the rate of early tricuspid flow E from 40 years of age (F=12,5; p=0,0000001). Similarly, was the reduction of the ratio E/A (F=14,7; p=0,0000001), in contrast to the flow velocity of atrial systole (A), which in all groups remained stable (F=1,3; p=0,25). Tricuspid FPV significantly decreased progressively from 30 years of age. There were significant correlation of FPV with age using Pearson's coefficient (r=-0,42; p=0,0001).Thus, tricuspid flow propagation velocity is significantly reduced with ageing and has with him a significant correlation. These studies may be useful in echocardiography study of diastolic function of the right ventricle.

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