P459Evaluation of aortic elastic properties in patients with fibromyalgia.


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Abstract

Purpose: Fibromyalgia (FM) is a chronic syndrome which is characterized by widespread pain and tender points. Chronic high sympathetic activity may lead to various negative cardiovascular responses in patients with FM. Elastic properties of the aorta in patients with fibromyalgia were investigated in this study.Methods: Forty eight women with FM and 30 healthy control were enrolled. Systolic and diastolic diameters of the ascending aorta were measured by using transthoracic echocardiography. Systolic and diastolic blood pressures were measured. Elastic parameters of aorta were calculated by pre-determined formulas. Additionally FM patients subdivided into two groups according to FIQ (Fibromyalgia Impact Questionnaire) scoring as severely symptomatic (group A, FIQ> 70) and less symptomatic (group B, FIQ <70).Results: The value of aortic distensibility was not different between patients with fibromyalgia and control (3.89±1.2 cm2/dynes10–6 vs 4.03±0.6 cm2/dynes10–6, p = 0.55). Aortic stiffness index was significantly higher in patients with fibromyalgia than the control group (4.44±1.52 vs 3.79 ±0.72, p=0.03). Aortic distensibility was significantly lower (3.18±1.35 vs 4.00 ±0.99 and 4.03±0.6, p= 0.03 and 0.007 respectively) in the group A than the group B and control. There was no significant difference between group B and the control group (p = 0.88). Aortic stiffness index was significantly higher (5.85±1.48 vs 3.97±1.23 and 3.79±0.72, p=0.001 and p<0.001 respectively) in the group A than the group B and control. There was also no significant difference between group B and the control group (p =0.48).Conclusion: The aortic stiffness index was significantly higher in patients with fibromyalgia than control. Aortic stiffness index increased much more in severely symptomatic patients. Aortic distensibility value was decreased significantly in patients with severe fibromyalgia but there was no difference between less symptomatic patients and the control group. This findings suggest that elastic properties of aorta is impaired in patients with severly symptomatic fibromyalgia.

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