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Purpose: Left ventricular (LV) mass is an important clinical variable in predicting morbidity and mortality in a variety of cardiac diseases. Cardiovascular magnetic resonance (CMR) is considered the gold standard for reliable quantification of LV hypertrophy. Three-dimensional echocardiography (3DE), by eliminating geometric assumptions applied in conventional echocardiography, also provides an accurate and reproducible assessment of LV mass. However, data comparing LV mass measurement using these two techniques is still limited. Our study aimed to address the reliability of 3DE for LVmass estimation in contrast to CMR.Methods: Sixty-two normal controls (Mean age 57 ± 15yrs, 29 male) underwent CMR and 3DE for evaluation of LV function. LV mass and volumes were calculated blindly using the appropriate soft-wares by two different investigators. Pearson's correlation coefficient and Bland Altman plots were used to assess the strength between the two techniques.Results: The corresponding r values for LV mass and indexed mass (LVMI) were 0.91 and 0.89, respectively, P<0.001. The bias, 95% CI, and P value for LV mass were 1.7, -0.8 to 4.3, P=0.175 and for LVMI were -0.8, -2.3 to 0.8, P=0.322. The plots are given in Fig. The r values for LV volumes in diastole and systole were 0.94 and 0.93, respectively, all P<0.001.Conclusion: The results of this study showed that 3DE provides an accurate and reliable estimate of LV mass comparable to CMR in normal subjects.