P481Association of left atrial myocardial function with left ventricular diastolic dysfunction in subjects with preserved systolic function: a strain rate imaging study

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Background: patients with diastolic heart failure (DHF) suffer from a rising morbidity and mortality. Left atrial (LA) strain by two dimensional speckle tracking can represent a new tool to evaluate LA function. The purpose of this study is to investigate the relationship between LA function and left ventricular (LV) diastolic function in subjects with diastolic heart failure.Method: thirty subjects with left ventriclular diastolic dysfunction (M : F = 10:20, mean age, 44 ± 10 years)and 30 healthy control patients(M:F = 16 : 14, mean age: 38 ± 15)were enrolled. Peak atrial longitudinal strain(PALS), LA volumetric data were obtained to evaluate LV function.Results: Compared with patients of normal diastolic function, the diastolic dysfunction group had significantly lower PALS(45.6 ± 15.8 vs 39 ± 3 %, p = 0.012), passive LA emptying fraction(29.6 ± 8.1 vs 22 ± 5 %p = 0.029). In the patients with diastolic heart failure, E/E' had significant correlation with LA strain(r= -0.38, p=0.024), LA passive EF(r= -0.554, p=0.014), but LA EF(r= -0.48, p=0.412)LA active EF(r=-0.38, p=0.528) revealed no significant correlation with E/E'Conclusion: By using speckle tracking echocardiography, LA longitudinal strain could be useful in patients with diastolic dysfunction. LA strain, LA passive fraction were significantly reduced in patients with DHF.

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